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2 days) induced exogenous DPX in POE tissues such as nasal passages in both species, but not in distal tissues, such as bone marrow and peripheral blood monocytes (rats and monkeys) and liver (monkeys), although endogenous DPX were detectable in all tissues (see Table C-9)

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Like semaglutide, tirzepatide enhances insulin sensitivity and suppresses appetite—but adds the GIP pathway for potentially even more profound effects